NAD+ IV Therapy

What is NAD+?

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of your body, playing a critical role in energy metabolism, DNA repair, cellular communication, and hundreds of other essential biological processes. NAD+ is so fundamental to life that without it, cells would die within seconds.

As we age, NAD+ levels decline dramatically—by age 50, most people have approximately 50% less NAD+ than they did in their youth. This decline is now recognised as one of the primary drivers of ageing and age-related disease. Declining NAD+ impairs mitochondrial function (reducing cellular energy production), compromises DNA repair mechanisms, disrupts circadian rhythms, and accelerates cellular senescence.

The exciting discovery is that restoring NAD+ levels through supplementation or intravenous therapy can reverse many of these age-related changes, effectively rejuvenating cells and improving function across multiple organ systems.

The Science Behind NAD+ and Longevity

NAD+ sits at the intersection of multiple longevity pathways that have been extensively studied in ageing research:

Mitochondrial Function & Energy Production

NAD+ is essential for the electron transport chain—the process by which mitochondria generate ATP, the energy currency of cells. Higher NAD+ levels mean more efficient energy production, which translates to better physical performance, cognitive function, and overall vitality. Studies show that boosting NAD+ can improve mitochondrial function in aged cells to levels comparable to young cells.

DNA Repair & Genomic Stability

Every day, your DNA sustains thousands of damage events from normal metabolism, environmental exposures, and replication errors. NAD+ is required for the function of PARP enzymes, which repair DNA damage. When NAD+ levels are low, DNA repair is impaired, leading to accumulation of mutations and cellular dysfunction. Restoring NAD+ enhances DNA repair capacity, protecting genomic integrity.

Sirtuin Activation

Sirtuins are a family of proteins often called "longevity genes" because of their role in regulating ageing, inflammation, and stress resistance. Sirtuins require NAD+ to function—they literally consume NAD+ as fuel. Higher NAD+ levels activate sirtuins, which in turn promote cellular health through multiple mechanisms including improved metabolism, enhanced stress resistance, and reduced inflammation.

Cellular Senescence & Inflammation

NAD+ helps clear senescent cells (aged, dysfunctional cells that accumulate with age and secrete inflammatory factors) and reduces chronic inflammation. This is significant because cellular senescence and chronic inflammation are major drivers of age-related disease.

Benefits of NAD+ IV Therapy

Patients undergoing NAD+ IV therapy commonly report improvements across multiple dimensions of health and wellbeing:

Why IV Administration?

Whilst oral NAD+ precursors (such as nicotinamide riboside and nicotinamide mononucleotide) can raise NAD+ levels, intravenous administration offers several distinct advantages:

Superior Bioavailability

IV administration delivers NAD+ directly into the bloodstream, bypassing the digestive system entirely. This results in 100% bioavailability compared to oral supplements, which must survive stomach acid and first-pass metabolism in the liver. The result is dramatically higher NAD+ levels achieved more rapidly.

Immediate Cellular Uptake

When administered intravenously, NAD+ is immediately available to cells throughout the body. Many patients report feeling the effects—particularly increased energy and mental clarity—within hours of their first infusion.

Therapeutic Dosing

IV therapy allows us to administer therapeutic doses (typically 250-1000mg) that would be impractical or impossible to achieve through oral supplementation. These higher doses are particularly beneficial for addressing significant NAD+ depletion or achieving rapid improvements.

Customizable Protocols

IV administration enables us to combine NAD+ with other beneficial compounds such as B vitamins, amino acids, glutathione, and minerals, creating synergistic formulations tailored to your specific needs.

The NAD+ IV Therapy Experience

Initial Consultation

Before beginning NAD+ therapy, you'll have a consultation with one of our physicians to discuss your health goals, review your medical history, and determine the optimal protocol for your needs. We'll explain what to expect during infusions and answer all your questions.

The Infusion Process

NAD+ IV therapy takes place in our comfortable infusion suite. You'll be seated in a reclining chair with access to entertainment, refreshments, and WiFi. A small IV catheter is placed in your arm, and the NAD+ infusion begins.

Infusion duration varies based on dose and individual tolerance, typically ranging from 2-4 hours. We start slowly to assess your tolerance and can adjust the infusion rate based on your comfort. Some patients experience mild sensations during infusion—such as warmth, tingling, or mild nausea—which resolve quickly when the infusion rate is reduced.

Immediate Effects

Many patients notice improvements in energy and mental clarity within hours of their first infusion. These acute effects typically last 3-7 days initially, with cumulative benefits building over a series of treatments.

Recommended Protocols

For optimal results, we typically recommend an initial series of 4-8 infusions over 2-4 weeks, followed by monthly maintenance infusions. The exact protocol is personalised based on your goals, response, and lifestyle factors.

NAD+ Therapy Protocols

Standard Protocol (500mg)

Our most popular protocol delivers 500mg of NAD+ over 2-3 hours. This dose is well-tolerated by most patients and provides significant benefits for energy, cognitive function, and overall wellbeing. Recommended for general health optimization and anti-ageing.

High-Dose Protocol (750-1000mg)

Higher doses are used for more intensive interventions, such as addressing significant fatigue, supporting recovery from illness or stress, or maximising anti-ageing benefits. Infusion time is typically 3-4 hours. Recommended for patients seeking maximum therapeutic effect.

Maintenance Protocol (250-500mg)

Once you've completed an initial loading series, monthly maintenance infusions help sustain elevated NAD+ levels and preserve the benefits achieved. Many patients incorporate monthly NAD+ infusions into their ongoing longevity programme.

Enhanced Formulations

We offer customised IV formulations that combine NAD+ with complementary nutrients:

• NAD+ Performance: NAD+ plus B vitamins, amino acids, and minerals for enhanced athletic performance and recovery
• NAD+ Cognitive: NAD+ plus nutrients that support brain health and cognitive function
• NAD+ Detox: NAD+ plus glutathione and other antioxidants for cellular detoxification

Who Should Consider NAD+ IV Therapy?

NAD+ IV therapy is appropriate for a wide range of individuals seeking to optimise health and slow ageing:

• Health-conscious individuals aged 35+ interested in proactive anti-ageing interventions
• Those experiencing fatigue or declining energy despite adequate sleep and healthy lifestyle
• Executives and professionals seeking enhanced cognitive performance and mental clarity
• Athletes wanting to improve performance, endurance, and recovery
• Individuals with family history of age-related diseases seeking preventative strategies
• Anyone implementing a comprehensive longevity programme who wants to maximise cellular health

Safety & Contraindications

NAD+ IV therapy has an excellent safety profile when administered by experienced medical professionals. Side effects are typically mild and transient, most commonly including:

• Mild nausea or stomach discomfort (usually resolves with slower infusion rate)
• Warmth or tingling sensations
• Mild headache
• Temporary flushing

NAD+ therapy is contraindicated in pregnancy and breastfeeding. Patients with certain medical conditions should discuss their suitability with our physicians during consultation.

Investment

NAD+ IV therapy pricing varies based on dose and formulation:

• 250mg NAD+ infusion: £350
• 500mg NAD+ infusion: £550
• 750mg NAD+ infusion: £750
• 1000mg NAD+ infusion: £950

We offer package pricing for initial loading series (4-8 infusions) with savings of 10-15%. Patients enrolled in our concierge membership programme receive preferential rates on all NAD+ therapy.